What is Methylcobalamin B12?

What is Methylcobalamin B12?

What is Methylcobalamin B12 and Why is it Special?

Methylcobalamin B12, pronounced, “Meth-yl-co-bal-a-min”

Hard to say, harder to spell, but so good for you.

No need to correctly pronounce or spell this funny word. Methylcobalamin is not easily offended and will still benefit your health.

How about this one? Vit-a-min Bee-twelve. Yep. Vitamin B12. That was easy.

Methylcobalamin is an active coenzyme form of vitamin B12 that easily absorbs in the body to be used effectively right away.

Let’s share a bit about why methylcobalamin is a well-loved form of vitamin B12 and how it is different from a vitamin B12 counterpart — cyanocobalamin. 

Cyanocobalamin vs. Methylcobalamin

The two most common forms of Vitamin B12 (cobalamin) are cyanocobalamin and methylcobalamin.

While both are beneficial forms of vitamin B12, cyanocobalamin requires a step-by-step conversion process in the body to be fully utilized. Cyanocobalamin must be enzymatically converted in the body into an active coenzyme form, such as S-adenosylcobalamin or methylcobalamin. 


-Supports healthy vitamin B12 levels
-Benefits healthy metabolism, blood cells, nervous system, and cognitive function


-People with MTHFR gene have a difficult time converting this form in the body
-Synthetic version of vitamin B12
-Requires a step-by-step methylation process to be absorbed in the body

Methylcobalamin is the active coenzyme form of vitamin B12 that is naturally found in food. It is attached to a methyl group. The body quickly identifies with this form since it is accustomed to methylation processes. Methylcobalamin is often recommended for metabolic and therapeutic benefits not offered by other forms of vitamin B12.


– Supports healthy vitamin B12 levels
– Benefits red blood cell formation and methylation reactions
– Assists brain and nervous system function and immune regulation
– Quickly absorbed in the body
– Pre-activated and does not need to be converted in the body
– People with MTHFR gene are able to utilize this version in the body


– It may be more expensive in supplement form

More nutrition facts about Methylcobalamin

Supports other nutrients in the body

Methylcobalamin helps with the transfer of methyl groups as an essential cofactor for methionine synthase. This critical enzyme is required for healthy homocysteine levels. Methylcobalamin is also involved in the process that produces dopamine and serotonin to support a healthy mood.

Helps regenerate neurons

Methylcobalamin is a crucial donor of methyl groups to the myelin sheath that insulates nerve fibers and regenerates damaged neurons. 

Improves nerve function and sensory

Methylcobalamin has been shown to improve sensation and other symptoms for people who have blood sugar imbalances. It may also lessen pain, numbness, or tingling.

Healthy homocysteine levels

A combination of methylcobalamin and folic acid can benefit the balance of homocysteine levels. Both folic acid and vitamin B12 are required for the remethylation pathway to regain and maintain normal activity. 

Benefits children with autism

A growing body of evidence finds that children with autism may have nutrient deficits for many reasons. With its many benefits on the nervous system and methylation processes, Methylcobalamin is considered an essential nutrient for children with autism who may have impaired methylation chemistry and other compromised processes. 

Methylcobalamin Indications

Methylcobalamin is taken the same way you take a vitamin B12 supplement. Many Complex B Vitamins contain this active form. It may be particularly useful for individuals with impaired methylation processes, including those with elevated homocysteine or neurological weaknesses.

Safety: Oral forms of vitamin B12 (cobalmin), including Methylcobalamin, have been shown to be safe and well tolerated. Current research suggests it is often as equally effective, more cost-effective, and better tolerated than intramuscular vitamin B12 injections.

Adverse Reactions: None Reported.

Contraindications: None Reported.

Drug Interactions: Vitamin B12 should be taken at different times of the day from tetracycline. Use of metformin for diabetes, acid-reducing medications for ulcers, and long-term treatment with phenobarbital or phenytoin for seizure disorders may interfere with the body’s ability to use vitamin B12.


Bolaman Z, Kadikoylu G, Yukselen I, et al. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clin Ther 2003;25(12):3124-3134.
Coelho D, et al. The cblD defect causes either isolated or combined deficiency of methylcobalamin and adenosylcobalamin synthesis. J Biol Chem 2004;279(4):42742-42749.
Elia M. Oral or parenteral therapy for B12 deficiency. Lancet 1998;352:1721-1722.
James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec;80(6):1611-7.
Kelly G. The coenzyme forms of vitamin B12: toward an understanding of their therapeutic potential. Alt Med Rev 1997;2(5):459-471.
Koyama K, Usami T, Takeuchi O, et al. Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation.
Kuwabara S, Nakazawa R, Azuma N, et al. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-475.
Kuzminski A, Del Giacco E, Allen R, et al. Effective treatment of cobalamin deficiency with oral cobalamin. Blood 1998;92(4);1191-1198.
Leal N, Olteanu H, Banerjee R, et al. Human ATP:Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase. J Biol Chem 2004;279(46):47536-47542.
Li G. Effect of mecobalamin on diabetic neuropathies. Beijing methylcobal clinical trial collaborative group. Zhonghua Nei Ke Za Zhi 1999;38(1):14-17. Nephrol Dial Transplant 2002;17:916-922.
Oh R, Brown D. Vitamin B12 deficiency. Am Fam Physician 2003;67:979-986.
Okuda K, Yashima K, Kitazaki T, et al. Intestinal absorption and concurrent chemical changes of methylcobalamin. J Lab Clin Med 1973;81:557-567.
Solomon L. Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing. Blood 2005;105:978-985.
Suormala T, Baumgartner M, Takasaki Y, Moriuchi Y, Tsushima H, et al. Effectiveness of oral B12 therapy for pernicious anemia and vitamin B12 deficiency anemia. Rinsho Ketsueki 2002;43(3):165-169.
Tsukerman E, Pomerantseva T, Poznanskaia A, et al. Effect of methylcobalamin and adenosylcobalamin on the process of hematopoiesis and vitamin B12 exchange in experimental phenylhydrazine-induced anemia in rabbits. Vopr Med Khim 1989;35(1):106-111.
Weir D, Scott J. Vitamin B12 “Cobalamin.” In: Maurice E. Shils, ed. Modern nutrition in health and disease, 9th edition, Lippincott Williams & Wilkins, 1999:447-458.
[Applied Health Publications are registered in the United States Library of Congress, ISSN: 1525-6359]
Back to blog