Knee Pain & Active People - Knees Need CellRenew Collagen Type 2
Please Note:

On behalf of Applied Health, our thoughts and prayers go out to all those affected by hurricane Florence, especially the safety workers and early responders who have left their own homes and families to assist others in need.

Our knees were designed to last a lifetime…


When a lifetime was 50.


How do you promote healthy knees?

How to prevent knee pain:

Available @ Applied Health

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CellRenew PRO for the Win!

CellRenew STS (Soft Tissue Support) is for a Milder Maintenance Response

Pop Quiz Answer Sheet

Q: What is the most abundant protein in the human body?
A: Collagen is the most abundant protein in your body, responsible for providing structure to the connective tissue that includes bones, tendons, cartilage, organs, and skin.  The word “Collagen” comes from the Greek word kólla, which means glue.  Without it, you would be a puddle on the floor.

Q: Of the more than 20 types of Collagen in our bodies, what are the most common?
Collagen Types I, II, and III make up the greatest percentage of collagen proteins in our bodies.

Q: What type of Collagen is most important for healthy joint function?
Collagen Type II is the most vital type of collagen for healthy joints. It is very high concentration in the cartilage, which provides the slippery cushion on which the moving parts ride.


Healthy Knee Joint

It is rare to discuss arthritis, without discussing the knees. This is because, as a weight-bearing joint, and due to the knee’s complicated structure, they are the most susceptible to wear, overuse, abuse and trauma due to an active lifestyle.

As such, the knees tend to be the “Poster Child” whenever the topic turns to arthritis symptoms.  From there, it is simple to draw a conclusion; if something is designed to help the knees, then it will also benefit every other joint in your body, whether it is weight-bearing or not.

Hyaluronic Acid is Lube for Your Squeaky Hinge

Hyaluronic Acid is like a big sponge, able to hold 1,000 times its own weight in water. slippery-when-wet-400w
Hyaluronic Acid (HA) is in high concentration in the joints as a major component of synovial fluid, helping increase the viscosity to increase lubrication and cushion.

Imagine what would happen if you ran your car’s engine out of oil.  Then imagine the results when your joints lose their lubrication.

Keep your parts slippery.

Every serving of CellRenew PRO contains 200 milligrams of Hyaluronic Acid.

How to Heal and Protect Active Knees
(4 minutes)


Most Popular Products

CellRenew Collection
Joint & Soft Tissue Support

Our Collagen Type II-Based products continue the tradition of excellence that began with the first product in 1997.
The original product’s legacy is bred into every product.
[Each item available individually.]

More Information

Every day, your knees support the Space Shuttle’s weight at launch.

In the 60’s, Japanese walking clubs defined “10-thousand steps per day” to be the benchmark for being an “Active” adult. At the time, Japanese research estimated the average person walked only 3,500 – 5,000 steps each day.

The distinction originated in 1965 when the watch company, Yamasa Tokei, introduced the first pedometer (counts steps) with the slogan, “Let’s all walk 10,000 steps a day!” From there, 10-thousand steps became synonymous with the minimum steps it takes to be reasonably healthy.

Since then, it has inspired countless programs and daily routines, and become synonymous with the threshold at which a healthy adult is considered “active”, or not.

(Related: “Why Does 10-Thousand Steps Define Healthy Activity)

For this reason, it is useful to consider 10,000 Steps as a base factor toward understanding the onslaught of forces your knee joints must withstand while sustaining the minimal levels of an active lifestyle.  With this understanding and perspective, we can take steps — if you will — toward proper care for these under-appreciated joints.

Won’t 10,000 Steps Take All DAY?!!

Although 10-thousand steps sound like a lot, it typically takes about 1 hour 15 minutes, at a brisk walk, equating to roughly 5 miles for the average stride.

And it should be noted that these steps do not need to be continuous steps to be beneficial. Getting up several times each day to walk down a hall and back can also provide results, and you will be surprised how fast the counts add up.

Even the National Institutes of Health agree…

The NIH has further classified daily step counts to define additional activity levels.

National Institutes of Health Indices for levels of activity, including 10-Thousand Steps.


Knees by the numbers (how it adds up):

  • 2 – 3 times:  The multiplier of body weight on each knee, with each step, while walking on level ground1,2
  • 180 pounds:  The average weight of an American (male=195, female=166)3
  • 450 pounds: Force applied to each knee, with each step, while walking on level ground (180 x 2.5 = 450)
  • 4.5 Million Pounds: Accumulation of cyclic forces as applied to your knees, each day, for a minimally “active” adult (10,000 steps x 450 = 4,500,000 pounds)


4.5 Million Pounds is also the weight of the Space Shuttle at the time of liftoff from the launch pad.4

Yeah… No wonder your knees hurt!

You can see why the stresses of an active lifestyle — day after day, year after year — can result in your knees craving proper care and nutrition.

CellRenew Customer Stories

James-DeVries-EdD-160x160I have been taking CellRenew since May of 2003. I attribute my continued ability to be active to this product. In 2006 I had arthroscopic surgery on my right shoulder and was told by the physician that I needed a shoulder replacement. I did not llke the diagnosis, and over the next year sought another opinion. I found a surgeon who said I had enough cartilage and he could fix me. So in 2007 I had my right shoulder completely rebuilt. While I am weaker, I have 90% range of motion and can do most things. Among my activities was a 15 day camping-portage canoe venture in Isle Royale. This product has kept my arthritis at bay. I am still active at 75.
James E. DeVries, Ed.D., Monroe, MI
I just wanted to send you this letter to thank you for the dramatic results I have experienced in the first three weeks of taking CellRenew. For the past twenty years, I have been living with severe lower back pain. I was diagnosed with a degenerative disc disorder in the L2,L3, and L4 vertebrae. Orthopedists have recommended cortisone injections or surgery. Both were unacceptable to me. CellRenew has improved my quality of life one thousand percent. I am truly grateful to all the people at Applied Health Solutions. I highly recommend this product to everyone I know personally and to anyone else who suffers with pain every day. I have also told my orthopedic surgeon, physical therapist, and even my chiropractor, who treated me twice a week.
Words cannot truly describe the way I feel. Thank you again and again!!
Greg L, Greer, South Carolina
I wanted to tell you all about how thrilled I am with CellRenew. I have been taking CellRenew for just over a year now. I have not had a single ache or pain in at least 10 months. I have experienced no side effects, except for one good side effect. I have changed my eyeglass prescription, twice! Both times were for the better! My eyesight is improving. What could be better than that?
Sally P, Melbourne, Florida
ArleneButtars-160x160I just visited my doctor. He says that I am amazing and wanted to know what I am doing, and what I am taking. I talked about CellRenew and how I have been taking it a couple of years. It has made an amazing difference in my knees. My doctor took down all the information. It really works as an antiaging product. I know I feel a lot better with it, than I would have without it.
Arlene B, Apache Junction, Arizona
CellRenew hydrolyzed collagen is working!  My knee is coming around.  Hopefully, I will be running again in the not too distant future.  I want to start training for a triathlon, next year – no, not the Iron Man.  I’m not quite that good.  I will keep you posted, but so far, CellRenew is making a definite difference.
Pat C., Lebanon, Ohio
Fourteen months ago – diagnosed with scoliosis, osteoarthritis of the spine and degenerative disc disease – my active life was gone, by all indications, forever. I was in excruciating pain most of the time. Putting on shoes or stockings, or climbing into bed caused screaming pain. On the xray, my spine looked like a rock pile.
I went on company disability, eventually returning to work part-time, but had to rest flat on my back with ice packs when not working. Enter CellRenew, and within one month, the improvement was incredible.
That was four months ago. Yesterday, I reloaded medium-weight boxes into my storage unit. The day before on hands and knees, I scrubbed the kitchen floor. The weekend before, I walked the mall briskly for 2-1/2 hours — and then tromped up and down stairs looking at condos with my son, for another hour. I have my life back. I know that CellRenew works!
Nancy P, Albuquerque, New Mexico
I have been using CellRenew for several years, now. I am very happy with the product. Not only is it helping all my joints, skin, hair, etc…, I have noticed recently that my thumbs don’t make the popping, snapping noise that they used to make. What a fabulous product.
Marlene B, Rehoboth Beach, Delaware

In the beginning…

Bill Evans, President, Applied Health, at North Field Testing Office

Bill Evans, President,
Applied Health


Over 20 Years Ago, I had a problem… I turned 40.

Okay, it wasn’t a problem so much as a challenge.

After a lifetime of outdoor antics, long-distance adventures and high-speed misbehaving, my lifestyle was finally catching up to me in the form of altered dreams and compromised goals due to rapidly progressing arthritis.

Too many years of racing motorcycles, hiking, mountain biking, skiing, and various other Adrenalin-inducing Shenanigans left me with a broken back, separated shoulder, broken elbow, twice-dislocated hip, and repeated broken knees.

I described my condition as that of a breakfast cereal… when I walked, I Snapped, Crackled and Popped!

Instead of a future filled with the pursuit of my favorite activities, and dreams of conquering the Bucket List, I only saw the prospect of surgeries, painkillers, and physical therapy.

I decided there had to be a better way than knee replacement and a cocktail of medications.

A year later, in 1997, we started Applied Health and introduced our first Collagen-based, joint support product using hydrolyzed collagen type II (2).

We called it CellRenew, and over 20 years later, we still have devoted users… myself among them.

I am now well into my 60’s, and though I have retired many of the Shenanigans, I still pursue my passions of hiking, mountain biking, and especially, offroad motorcycles.

You have seen just how quickly the stresses add up on your weight-bearing joints, in just one day.

How many times will you carry the weight of the Space Shuttle in a week, or a month? How many in 50 or 60 years of being active?

Yeah, your knees have reason to hurt…  It’s time to do something about it.

Available @ Applied Health

CellRenew PRO… It’s like meeting your knee’s best friend.

Frequently Asked Questions (FAQs)

CellRenew is a Hydrolyzed Collagen Type II dietary supplement developed for healthy joint support, and suggested through double-blind, clinical trials to be 89.9% effective. CellRenew contains very high concentrations of Hyaluronic Acid, a substance known for potent benefits to soft tissues and joint health.  The benefits of Collagen Type II are supported by published scientific data.
Unlike other protocols for arthritis symptoms, whether prescription or natural, CellRenew is guaranteed for results.  It is rare when you find a product – any product – with such a high success rate that the manufacturer will stand behind it with a money back guarantee. And since 1997, CellRenew has been worthy of this guarantee. It contains naturally occurring Hyaluronic Acid and Chondroitin Sulfate. The results of a human clinical trial using this material showed significant improvements in the reduction of joint swelling, tenderness, and pain, as well as successful increases in mobility.
Although studies have shown that many different conditions respond to Collagen Type II, the conditions that have shown the greatest response are rheumatoid arthritis and osteoarthritis. If you have grown weary of traditional protocols that only cover-up symptoms and neglect to address the root cause, then you are an excellent candidate to begin a program of Collagen Type II. CellRenew is also used as a preventative measure for athletes who have overworked their joints and are looking for a way to maintain healthy joints prior to the onset of osteoarthritis.
Collagen Type II (CTII) has been suggested to offer significant benefits for some types of arthritis. The word ‘arthritis’ is Latin, from Greek ‘arthro’ (joint) and ‘itis’ (inflammation). This very broad definition covers a lot of ailments but says nothing about the causes. The forms of arthritis that most of us are familiar with are osteoarthritis and rheumatoid arthritis. Osteoarthritis is usually caused by over-use, abuse, and injury. It is by far the most common form of arthritis. It is known that merely the aging process, and so many years of gravity working on the weight-bearing joints, is a major contributor to this type of arthritis. Osteoarthritis is not considered an autoimmune disorder (like rheumatoid arthritis) in which the body attacks itself as it would a foreign invader.

Rheumatoid arthritis (RA) is the most well known of the autoimmune types of arthritis. In the case of RA, the collagen in the joints is attacked. Though many sufferers notice that the problem gradually gets worse over the years (as they would for osteoarthritis), many experience a sudden ‘flare-up’ after a particular illness, often times a viral infection.

Depending on the particular type of arthritis you experience, CTII goes to work in different ways. If you suffer from RA, CTII acts as an oral tolerization agent, instructing the body to stop the immune response to the collagen in the joints. This natural response is the way that our bodies remain relatively free from immune or allergic reactions to most of the foods we eat. If we did not have this ability, we would eventually starve.

For those suffering from osteoarthritis, CTII provides the critical building blocks that restore a healthy state to the cartilage in the joints. CellRenew is made from chicken sternal cartilage that contains the highest level of naturally occurring anti-inflammatory proteoglycans (Hyaluronic Acid and Chondroitin Sulfate A) of any other material tested, including shark cartilage. It is important to note that the combination of the proteoglycans and the Collagen Type II proteins not only protect the cartilage but also provide the building blocks required to rebuild lost cartilage to restore the joint to a normal state.

The results of a recent double-blind, placebo-controlled, clinical trial has proved the benefits of Collagen Type II for treating the symptoms of pain and immobility associated with arthritis. Drs. K. Buckman and J. Gutierrez report an 89.9% positive response rate, within 45 days, for the participants who consumed at least 2000 mg of Collagen Type II per day.

Back in 1958, a Dr. John Prudden, former professor of surgery at the College of Physicians and Surgeons of Columbia University, discovered that cartilage dramatically accelerated wound healing after he applied it as a topical agent. He later discovered the anti-inflammatory properties after applying it to a chronic ulcer a patient had on his skin. In the mid-sixties, Dr. Prudden joined with Dr. John Allen to conduct a study of non-healing wounds and the use of Collagen Type II-rich cartilage. The result was a 42% improvement between the treated wounds and the control wounds. This difference was considered highly significant. Then, Dr. Prudden reported having successfully treated more than 50 patients, starting in 1974, with osteoarthritis, rheumatoid arthritis, psoriasis, and many other ailments.

In 1968, Dr. A.J. Bollet’s research showed that the Collagen Type II-rich cartilage promoted protein and chondroitin sulfate synthesis, key components in the bodies construction of cartilage. Of the different types of cartilage tested, the one with the highest level of Collagen Type II, anti-inflammatory proteoglycans (the healing properties) was chicken sternal cartilage. CellRenew is 100% chicken sternal cartilage.

Besides the better-known associations with osteoarthritis and rheumatoid arthritis, it has also been suggested that Collagen Type II might benefit heart disease, psoriasis, progressive myopia, and some other autoimmune diseases. Many realize other benefits that were less anticipated but quite appreciated for aesthetic reasons. Because collagen is a key building block for several processes of the body, many people notice their nails grow noticeably faster, their hair strands get thicker, and their skin becomes softer.

There is also a lot of enthusiasm in the sports and fitness community about CellRenew because of the preventative qualities for offering a protective factor to cartilage in over-stressed joints, and promoting a full range of motion for sports that require repetitive or exaggerated movements like golf, martial arts, tennis, jogging, and weightlifting.

No, unless you want to consider healthier nails, hair, and skin a side effect. CellRenew is water soluble and has never been indicated in any toxic buildup.
Although some people have noticed an improvement with their symptoms after only a week or two of starting a CellRenew program, many take between 4 and 6 weeks. We urge you not to get impatient with your progress. A recent clinical trial reports an 89.9% response within 45 days. Remember that these are natural based, non-toxic, core nutritionals that are not designed to just cover up symptoms. Instead, they are designed to correct a problem that has often been present and ignored for many years. In most cases, it took many years to get to a state of the particular complaint, and rarely are root causes improved on overnight.

With that said, however, we have noticed that some forms of arthritis symptoms tend to respond faster – on average – than other forms.  For instance, we do know that rheumatoid arthritis sufferers have a tendency to respond faster, and curiously, people who have spinal discomforts notice improvement typically in less time than someone with discomfort in one of their weight-bearing joints (knees, hips).  We suspect this is more an issue of the weight-bearing joints needing to develop a much greater degree of damage prior to showing symptoms than perhaps is required for a spinal condition.
The speed of your progress is also a function of your own responsibility to take control of your treatment. This means that you must commit to the healing process. Often times, we see people complain that they have not seen any progress after a couple of weeks, and when pressed for answers as to how they are following the program, they admit to forgetting to take the CellRenew half the time. Or they always take it after a big meal or a pot of coffee. Once your condition has stabilized after several weeks or months of improvement, and you want to settle into a ‘maintenance mode’, then you can get away with ‘forgetting’ to take it, or not taking it at the optimum time. But until then, please be disciplined. You will thank yourself later.

Yes, but it is not recommended to take prescription medications at the same time as nutritional supplementation. Wait at least 20 minutes after taking CellRenew before taking any medication.  This is not for concern of effecting the drug; CellRenew is quite safe with any interactions. The reason we ask that you wait to take anything else is to minimize the chance that CellRenew might bind with some other material and not get fully absorbed.

Collagen Type 2 Stops Knee Pain

Available @ Applied Health

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CellRenew Collagen Type II is the Right Choice

When you change the oil in your car, do you compromise with a brand that has only half the lubricating properties?

Of course not.

Even if you save a couple bucks, making the wrong choice when choosing lubrication for your engine will result in disaster… and a much higher expense, later.

As an “active” adult, the same principle applies when you choose how to nourish and lubricate your hard-working joints.  You need a full 2000 milligrams of collagen type II to compensate for the daily stresses that “10,000 steps” imposes on your joints.

If that reason is not compelling enough, remember . . . there are 4.5 million more.

Since 1997, CellRenew Collagen Type II has only been made with the full 2000 milligrams in each dose, including 200 milligrams of Hyaluronic Acid.

When you are restoring or maintaining the health of your weight-bearing joints, compromise is not an option.

CellRenew… Never Compromise.

Reflecting on Our Mission, 20 Years Later
(2 minutes)

Is Collagen Type 2 a Cure for Arthritis and Heart Disease?


1 Darryl D. D’Lima,i Benjamin J. Fregly,ii Shantanu Patil,i Nikolai Steklov,i and Clifford W. Colwell, Jr.i; Knee joint forces: prediction, measurement, and significance; Proc Inst Mech Eng H. Feb 2012; 226(2); 95–102. iScripps Health, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, USA  iiUniversity of Florida, Dept of Mechanical & Aerospace Engineering, USA
2 Darryl D. D’Lima, MD, PhD,corresponding author Shantanu Patil, MD, Nicolai Steklov, BS, and Clifford W. Colwell, Jr, MD; The 2011 ABJS Nicolas Andry Award: ‘Lab’-in-a-Knee: In Vivo Knee Forces, Kinematics, and Contact Analysis; Clin Orthop Relat Res. Oct 2011; 469(10): 2953–2970.; Published online May 20, 2011;
3 Center for Disease Control and Prevention (CDC), National Center for Health Statistics, Body Measurements (Data for U.S.), “Measured average height, weight, and waist circumference for adults ages 20 years and over”;;
Human Body Weight, Average Weight Around the World;
4 Space Shuttle Basics; National Aeronautics and Space Administration;

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