Monograph
Soothology Ultra Strength
Pain Soothing Gel


Description:

Soothology is a marine-based therapeutic gel formulated to ease muscles aches and tension. This lightweight, non-sticky formula goes on the skin smoothly and penetrates quickly delivering nutrients and minerals to help alleviate soreness.

Soothology is rich in red and brown marine algae and herbal extracts, including rosemary extract and essential oils of peppermint, that help reduce inflammation, relieve areas of discomfort, and support muscle recovery.

Soothology is preservative free.

 

Ingredients:

Caffeine

Caffeine has been shown to offer relief to muscle discomfort by lessening the sensation of discomfort on adenosine receptors that signal pain sensations.[1] Researchers found that caffeine can help reduce post-workout muscle soreness.[2] Another study found that caffeine significantly reduced muscle discomfort while exercising.[3]

 

Camellia Sinensis (Green Tea Extract)

Naturally rich in antioxidants, camellia sinensis is known for its anti-inflammatory properties and has been shown to help improve muscle recovery and reduce inflammation.[4],[5],[6],[7]

 

Camphor

Camphor comes from the wood of a camphor laurel tree (Cinnamomum camphora) and is often used in topical creams and lotions to alleviate muscle and joint discomfort. It is also known to lessen inflammation and is easily absorbed through the skin.[8] Camphor has been used in a variety of topical applications showing benefits in alleviating discomfort.[9]

 

Chlorophyll

Chlorophyll is high in vitamins A, C, E, and K and antioxidants that help protect against free radical damage. Chlorophyll can also lessen inflammation and is often used as a therapy for muscular health.[10],[11]

 

Chondus Crispus (Irish Moss)

 Irish moss is a type of red algae that is used as a natural emollient or thickening agent in topical products. Filled with antioxidants and a rich mineral content, including vitamin A, vitamin B1, iron, magnesium, and calcium, Irish moss is also used to lessen inflammation in tissue and hydrate the skin.[12]

 

Essential oils of Menta Piperita (Peppermint)

Peppermint has anti-inflammatory properties that can help alleviate muscle discomfort.[13] It has been found to reduce muscle tension, fatigue and support muscle relaxation.[14],[15],[16]

 

Ethyl Alcohol

Instead of being derived from petroleum or denatured products, ethyl alcohol is made from sugar cane. With a low molecular weight, ethyl alcohol is combined with topical ingredients to help the nutrients penetrate the skin.[17],[18],[19]

 

Glycerin

Glycerin is a natural compound found in animal and plant-derived fats. It promotes hydration and improves the application of topical therapies. It also contains anti-irritant and anti-inflammatory properties,[20] and is considered safe according to the European Working Group’s Skin Deep Database (EWG).

 

Glycolic Acid

Glycolic acid is commonly used in skin care products to moisturize and refresh the skin.

 

Hibiscus Extract

Hibiscus flower extract contains properties that lessen inflammation and has a therapeutic effect for a variety of medicinal purposes.[21] It includes anti-microbial and antioxidant properties to fight off free radical damage.[22]

 

Hydroxyethylcellulose

As a thickening agent and lubricant derived from cellulose, hydroxyethylcellulose is used in topical gels to help bind the formula together. It is considered safe and a non-irritant that is commonly used in skin care formulas.[23]

 

Isotonic Seawater

Isotonic seawater is considered a therapeutic agent with a mineral composition similar to blood plasma to absorb well into the body. It contains a third of the salt content of water found in the ocean and has the highest safety rating for skin care ingredients according to the Environment Working Group’s Skin Deep Database (EWG).

 

Lithothamnium Algae Extract

As mineral-rich red marine algae, Lithothamnium algae has 32 trace minerals, including selenium, zinc, copper, iodine, and chromium. This rich emollient penetrates the skin and contains properties that lessen inflammation.[24]


Menthol

Menthol is a topical muscle and joint reliever that offers a cooling sensation to temporarily lessen discomfort. When applied with methyl salicylate as a topical relief formula, menthol significantly alleviated discomfort in subjects with muscle strain.[25]

 

Porphyra & Laminaria Algaes

Porphyra and Laminaria are marine algaes known for their healing micronutrient properties. Porphyra red algae is made of properties and minerals that help soothe away inflammation.[26] Laminaria is a kelp that is rich in minerals, such as iodine, potassium, magnesium, calcium and iron, that are important to muscle health.

As an active ingredient in topical gels, laminaria may help reduce inflammation and support wound healing with anti-irritant actions.[27] Porphyra and laminaria have both been shown to have protective effects against lipid peroxidation that causes cellular damage.[28]

 

Red Algae

With antioxidant properties and essential minerals, red algae can inhibit inflammation and reduce oxidative stress in joints and tissue.[29],[30]

 

Rosmarinus Officinalis (Rosemary)

Rosemary supports muscle recovery after exertion, and has been used to soothe aches, lessen inflammation and improve circulation when applied topically.[31],[32]

 

Sodium Hyaluronate

Sodium Hyaluronate is a sodium salt that has beneficial properties similar to hyaluronic acid. It helps promote nutrient absorption, microcirculation and skin hydration. It has also been used for wound healing since the 1930s, and has been shown to significantly reduce joint discomfort.[33],[34],[35]

References:

[1] Baratloo A, et al. The role of caffeine in pain management: a brief literature review. Anesthesiology and pain medicine. 2016;6(3).

[2] Maridakis V, O’Connor PJ, Dudley GA, McCully KK. Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise. J Pain. 2007 Mar;8(3):237-43.

[3] Motl RW, O’Connor PJ, Dishman RK. Effect of caffeine on perceptions of leg muscle pain during moderate intensity cycling exercise. The Journal of Pain. 2003 Aug 1;4(6):316-21.

[4] Always SE, Bennett BT, Wilson JC, et al. Green tea extract attenuates muscle loss and improves muscle function during disuse, but fails to improve muscle recovery following unloading in aged rats. J of Applied Physiology. 2015;118(3):319–330.

[5] Asadi SY, Parsaei P, Karimi M, et al. Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat. Int J Surg. 2013;11(4):332-7.

[6] Evans NP, Call JA, Bassaganya-Riera J, et al. Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice. Clin Nutr. 2010 Jun;29(3):391-8.

[7] Maroon J, Bost JW, Maroon A. Natural anti-inflammatory agents for pain relief. Surgical neurology international. 2010;1.

[8] Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M. Camphor (Cinnamomum camphora), a traditional remedy with the history of treating several diseases. International Journal of Case Reports and Images (IJCRI). 2013;4(2):86-89.

[9] Nawaz A, Sheikh ZA, Feroz M, et al. Clinical efficacy of polyherbal formulation Eezpain spray for muscular pain relief. Pak J Pharm Sci. 2015 Jan;28(1):43-7.

[10] Subramoniam A, Asha VV, Nair SA, et al. Chlorophyll revisited: anti-inflammatory activities of chlorophyll a and inhibition of expression of TNF-α gene by the same. Inflammation. 2012 Jun;35(3):959-66.

[11] Park J, Park C, Kim J, et al. The Protective Effect of Chlorophyll Against Oxidative Stress and Inflammatory Processes in LPS-stimulated Macrophages. 2007; 16(2):35-41.

[12] Krishna S, Ramesh B, Kumar P., et al. A renewable biodiesel from micro-algae. Inter J of Pharma Dev & Tech. 4(2), 2014,119-125.

[13] Meamarbashi A, Rajabi A. The effects of peppermint on exercise performance. J International Society of Sports Nutrition. 2013 Dec;10(1):15.

[14] Kligler B, Chaudhary S. Peppermint oil. American Family Physician. 2007;75(7).

[15] Umezu T, Sakata A, Ito H. Ambulation-promoting effect of peppermint oil and identification of its active constituents. Pharmacol Biochem Behav. 2001, 69: 383-33.

[16] Genders R: The Complete Book of Herbs and Herb Growing. 1988, London: Ward Lock Limited

[17] Sintov AC, Shapiro L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J of Controlled Release. 2004 Mar 5;95(2):173-83.

[18] Vintiloiu A, Leroux JC. Organogels and their use in drug delivery—a review. J of Controlled Release. 2008 Feb 11;125(3):179-92.

[19] Berardesca E, Cameli N, Primavera G, Carrera M. Clinical and instrumental evaluation of skin improvement after treatment with a new 50% pyruvic acid peel. Dermatologic Surgery. 2006 Apr;32(4):526-31.

[20] Szél E, Polyánka H, Szabó K, et al. Anti-irritant and anti-inflammatory effects of glycerol and xylitol in sodium lauryl sulphate-induced acute irritation. J Eur Acad Dermatol Venereol. 2015 Dec;29(12):2333-41.

[21] Meraiyebu A, Olaniyan O, Eneze C, et al. Anti-inflammatory Activity of Methanolic Extract of Hibiscus sabdariffa on Carrageenan-Induced Inflammation in Wistar Rat. Int J of Pharmaceutical Science Invention. 2013;2(3):22-24.

[22] Kang PS, Seok JH, Kim YH, Eun JS, Oh SH. Antimicrobial and antioxidative effects of roselle (Hibiscus sabdariffa L.) flower extract and its fractions on skin microorganisms and oxidation. Food Science and Biotechnology. 2007 Jun;16(3):409-14.

[23] Barel AO, Paye M, Maibach HI. Handbook of Cosmetic Science and Technology. Informa Healthcare. 2009.

[24] Ryan S, O’Gorman DM, Nolan YM. Evidence that the marine-derived multi-mineral Aquamin has anti-inflammatory effects on cortical glial-enriched cultures. Phytother Res. 2011 May;25(5):765-7.

[25] Higashi Y, Kiuchi T, Furuta K. Efficacy and safety profile of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain: a randomized, double-blind, parallel-group, placebo-controlled, multicenter study. Clinical therapeutics, 2010;32(1):34-43.

[26] Berthon JY, Nachat-Kappes R, Bey M, et al. Marine algae as attractive source to skin care. Free Radic Res. 2017 Jun;51(6):555-567.

[27] Noor A. Skin restoration from the sea. https://oceanrescuespa.com/wp-content/uploads/2017/09/Ocean-Rescue-Signature-Series-Skin-Restoration-from-the-Sea-Noor.pdf

[28] Jiang Y, Wang L, Yao L, et al. Protective effect of edible marine algae, Laminaria japonica and Porphyra haitanensis, on subchronic toxicity in rats induced by inorganic arsenic. Biol Trace Elem Res. 2013 Sep;154(3):379-86.

[29] Sayed AA, Sadek SA, Soliman AM, Marzouk M. Prospective effect of red algae, Actinotrichia fragilis, against some osteoarthritis aetiology. African Journal of Traditional. 2017;14(1):231-41.

[30] Heo SJ, Cha SH, Lee KW, Jeon YJ. Antioxidant activities of red algae from Jeju Island. Algae. 2006;21(1):149-56.

[31] Peng CH, Su JD, Chyau CC, et al. Supercritical fluid extracts of rosemary leaves exhibit potent anti-inflammation and anti-tumor effects. Biosci Biotechnol Biochem. 2007 Sep;71(9):2223-32.

[32] Takaki I, Bersani-Amado LE, Vendruscolo A, et al. Anti-inflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models. J Med Food. 2008 Dec;11(4):741-6.

[33] Sharma P, Maffulli N. Tendon injury and tendinopathy: healing and repair. JBJS, 2005;87(1): 187-202.

[34] Oryan A, Moshiri A., Parizi A, Jahromi A. Repeated administration of exogenous Sodium-hyaluronate improved tendon healing in an in vivo transection model. Journal of tissue viability. 2012;21(3):88-102.

[35] Brandt K, Block J, Michalski J, et al. Efficacy and safety of intraarticular sodium hyaluronate in knee osteoarthritis. Clinical Orthopaedics and Related Research (1976-2007). 2001;385:130-143.